THE CHANGING LANDSCAPE OF EXPANDED ACCESS TO INVESTIGATIONAL DRUGS FOR PATIENTS WITH UNMET MEDICAL NEEDS: ETHICAL IMPLICATIONS

The changing landscape of expanded access to investigational drugs for patients with unmet medical needs: ethical implications

When patients are told that standard medical treatment options have been exhausted, their treating physicians may start looking for promising new drugs Pokers that are not yet approved, and still under investigation.Some patients can be included in clinical trials, but others cannot.It is not widely known that these patients might still be eligible

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Comparative analysis of avian poxvirus genomes, including a novel poxvirus from lesser flamingos (Phoenicopterus minor), highlights the lack of conservation of the central region

Abstract Background Avian poxviruses are important pathogens of both wild and domestic birds.To date, seven isolates from subclades A and B and one from proposed subclade E, have had their genomes completely sequenced.The genomes of these isolates have been shown to exhibit typical poxvirus genome characteristics with conserved central regions and

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Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds

Two major obstacles for successful cancer treatment are the toxicity of cytostatics and the development of drug resistance in cancer cells during chemotherapy.Acquired or intrinsic drug resistance is responsible for almost 90% of treatment failure.For this reason, there is an urgent need for new anticancer drugs with improved efficacy against cance

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